Post-Doctoral Fellow – Myosin Phosphatase

first_imgPost-doctoral research position in Division of CardiologyUniversity of MarylandA full time Post-Doctoral fellowship position is available in thelaboratory of Dr. Steven Fisher in the Division of Cardiology atthe University of Maryland-Baltimore as of October 1, 2020. Thefederally funded project examines vascular smooth muscle geneexpression and contractility in the regulation of blood flow indevelopment and disease models. The focus is on the myosinphosphatase (MP), a critical target of signals that regulate bloodflow. Experiments will test the hypothesis that editing of MPlowers blood pressure in models of hypertension and heart failure,and will determine the mechanism(s) by which it does so. Thepost-doc will perform experiments in animal models using Cre-Loxand AAV-Crispr/Cas9 editing of MP in vivo. The AAV-Crispr/Cas9approach of editing is in pre-clinical development as a noveltherapy for humans with hypertension and heart failure. Applicantsare required to have a Ph.D. or M.D. and expertise in techniques ofcell and molecular biology. Familiarity with experimentaltechniques required for the study of small blood vessels ispreferred but not required.If interested please email a CV, a short statement of researchinterests, and the names and contact information for threereferences to:Steven Fisher, MD, Professor of Medicine and Physiology, [email protected] Qualifications :Applicants are required to have a Ph.D. or M.D. and expertise intechniques of cell and molecular biology. Familiarity withexperimental techniques required for the study of small bloodvessels is preferred but not required.University of Maryland is an Equal Opportunity Employer encouragingexcellence through diversity. Qualified woman and minoritycandidates are encouraged to apply.last_img read more

Stack calls for utilities to notify towns of power shutoffs

first_imgUNION CITY – Following the death of a Newark woman in hospice care after PSE&G shut off her electricity, State Senator and Union City Mayor Brian Stack has called for PSE&G to notify municipalities of pending, non-emergency shut offs.“It is an absolute tragedy that a grandmother lost her life because her electricity was shut off and she was unable to use her oxygen tank,” stand said. “Municipalities are in a position to assist residents, either through their own resources or through social service agency resources. This should never occur because a resident got behind on her payments.”Stack has sponsored state Senate bill S-2477, which requires utilities providing electric, gas, or water services to notify the mayor, chief law enforcement officer, and health officer, in writing, at least 21 days prior to a non-emergency shut off. This would allow municipal officials, if needed, to intervene.“I have pleaded with PSE&G for over 20 years to change their policies and work with municipalities to prevent unnecessary shut offs,” Stank said. “Residents, especially the most vulnerable, must be protected to ensure that tragedies like this do not continue to occur. My heart goes out to Linda Daniel’s family, who watched her needlessly suffer.”last_img read more

Watch Umphrey’s McGee And Jennifer Hartswick Tear Up “Red Barchetta” At Red Rocks [Pro-Shot]

first_img[Photo: Jake Plimack]Setlist: Umphrey’s McGee | Red Rocks Amphitheatre | Morrison, CO | 7/2/2017Set 1: Nipple Trix > Get In The Van, Speak Up > Booth Love, Wizard Burial Ground, August, Cut Off > Ocean BillySet 2: Attachments, Day Nurse > 2nd Self, Red Barchetta[1], Mulche’s Odyssey, Slacker, Plunger, Electric Avenue to Hell[2]Encore: Puppet String > Glory > Puppet String[1] debut, Rush; with Jennifer Hartswick on vocals[2] with Jennifer Hartswick on vocals Ahead of 4th of July, Umphrey’s McGee took to the legendary Red Rocks Amphitheatre in Morrison, Colorado, for their first-ever three-night run at the famed venue. With support from Stick Figure on Friday, Bokanté and Snarky Puppy on Saturday, and Bruce Hornsby & the Noisemakers on Sunday, Umphrey’s headlining performances during the final two nights of the run saw a number of special sit-ins, including by the likes of Roosevelt Collier, Robert “Sput” Searight, Nate Werth, Chris Bullock, and Mike Maher. However, one of the most special moments of the weekend fell on Sunday, July 2nd, when Jennifer Hartswick joined the band during the second set of the night and final set of the weekend.Umphrey’s McGee Invites Jen Hartswick, Roosevelt Collier, And Snarky Puppy Members At Red Rocks Run [Video/Photos]Jennifer Hartswick has gained quite a reputation on the scene for her work with Trey Anastasio Band, her masterful trumpet playing, and her powerhouse vocals. No stranger to Red Rocks herself, Hartswick’s cameo during Umphrey’s 15th performance at Red Rocks came after her own performance there with TAB nearly a month prior. For her sit-in with Umphrey’s McGee, Jennifer Hartswick sat-in on vocals during the band’s debut of a cover of Rush’s “Red Barchetta.” The vocalist also provided her singing talents during the second-set closer of “Electric Avenue To Hell”—a mash-up of AC/DC’s “Highway to Hell” and Eddy Grant’s “Electric Avenue.”Recently, Umphrey’s McGee has released pro-shot video filmed by TourGigs of Hartswick’s first sit-in of Sunday night during Rush’s “Red Barchetta.” You can enjoy the video below.last_img read more

The Merry Widow’s Renee Fleming & Susan Stroman on Bringing B’way Flair to the Met

first_imgBroadway’s headed uptown! Well, up a few blocks, at least. Five-time Tony-winning director Susan Stroman is currently making her Metropolitan Opera debut with an effervescent mounting of Franz Lehár’s comic operetta The Merry Widow. The English adaptation, which opened on New Year’s Eve, stars Grammy-winning and Broadway-bound opera superstar Renée Fleming in the title role of Hanna. Joining her are fellow opera favorite Nathan Gunn and Great White Way darling Kelli O’Hara. Stroman and Fleming recently chatted with Broadway.com about bridging the gap between opera and musical theater, cross-genre dream productions and the showbiz sisterhood.Q: Susan, The Merry Widow marks your opera debut, and Renée, this is your first operetta. What was the biggest challenge while exploring this genre together?FLEMING: Well first, the dancing. Oh, those wonderful waltzing lessons from Susan. We’re highly rehearsed, which I needed. And secondly, dialogue at the Met. It’s an enormous challenge in a house that size to manage that much dialogue.STROMAN: It’s a huge space to conquer. Being in the opera world, the vocal and the music are the most important, so it’s making sure everyone is able to sing their high notes and that the staging is designed to support all the vocals.Q: Can you tell me more about the musical theater influences that you found in this piece?STROMAN: It’s very bubbly. Each of the three acts is infused with dance. For being 100 years old, it was really the beginning of a spark of musical comedy—of bringing different dance forms to opera.FLEMING: Opera tends to live in broad strokes and major themes: “I love you, I hate you, I’m going to kill you.” This has more of a Spencer Tracy and Katharine Hepburn feel to it.Q: Renée, what was it like working with Susan, compared to traditional opera directors?FLEMING: She’s so organized! An operetta is very quick moving; there’s not the languor that one has with the more romantic operas. The precision required for those of us who also don’t naturally have these skills needed her ability to see what had to get done and make sure we had enough time.Q: Susan, does it come naturally to you to work with artists who might not be traditionally trained in theater?STROMAN: I often come across folks who are more versed into one talent than the other, so I’m very used to trying to recognize someone’s talents and then help to develop the others. But I’m very ready to change and adapt, because I’m always inspired by the performers standing in front of me.Q: I imagine you had a similar process with ballet dancers in Little Dancer. Will we be seeing it in New York after L.A.?STROMAN: Yes, hopefully for next season! Fingers crossed.FLEMING: I want to see it!Q: Renée, what’s going through your head as you prepare to make your Broadway debut in Living on Love?FLEMING: Performing the play in the summer [in Williamstown] gave me a flavor for what it would be like. It was fantastic to have that sense of the audience. We don’t have that luxury on a huge opera stage. Of course, the cast might not be the same, and the play will be rewritten to some degree.Q: Have you been getting advice from Broadway alums about what it’s like?FLEMING: I saw Patrick Stewart, Sigourney Weaver, and David Hyde Pierce on opening night of Merry Widow and asked them to tell me what it’s like to be in a [Broadway] run. It sounds like a form of hermitism. [In opera], we can’t really sing more than two, three times max, a week. We have to have that downtime because it’s so vocally athletic. I can’t imagine what Kelli [O’Hara] does. It’s mind-boggling to me to be in a musical for eight shows a week.Q: After Living on Love, what show would we have to produce to get you to stay on Broadway in a musical?FLEMING: I honestly can’t imagine singing on Broadway. I wouldn’t know how to change my voice to put it into a place that would allow me to sing every day. I couldn’t imagine trying to do the physical taxing piece of it. And then to talk to Kelli, and have her say the same thing about opera! We’re just trained in different ways.STROMAN: I think Renée would be great as Desiree in A Little Night Music. Oh, she would be incredible.Q: Susan, if Renée stays downtown and you stay uptown, are there any other operas on your to-do list to direct?STROMAN: It’d be lovely to do a La Traviata or Carmen, but a brand new opera would be the most exciting. I’d love to take a contemporary composer like Rachel Portman or Alexandre Desplat and work with them.Q: Renée, between working with Susan and Kathleen Marshall, and Susan, directing Renée and Kelli, how does it feel to collaborate with such prolific female artists?FLEMING: First of all, there aren’t enough women directing in opera. I think women bring a particularly collaborative approach.STROMAN: Whenever I do a show in the theater, I try to have female assistants and observers; it’s very important to me to open their eyes to what it’s like to mount these big productions. To be in a room with Renée and Kelli and exploring art, opera and theater—I think it is a kind of sisterhood.Catch Fleming in The Merry Widow through January 31. Stroman’s production returns in April with a new cast. View Commentslast_img read more

Milkweed Pests

first_imgWith the fall migration underway for monarch butterflies through November, gardeners should soon start seeing the colorful creatures on their travels south. It’s also time to be on the lookout for pests of common milkweed (Ascelpias tuberosa), the most popular milkweed plant grown in Georgia butterfly gardens.The larval plant of the monarch butterfly is grown by gardeners across the state to assist in monarch conservation, but milkweed can also attract insects that are less welcome.The oleander aphid, Aphis nerii Boyer de Fonscolombe, uses piercing-sucking mouthparts to suck the juices out of the plant. Often called milkweed aphid, this pest can be a problem for young milkweed plants — older plants are more equipped to handle the damage.If aphids are damaging the milkweed in your garden, simply use a wet paper towel to remove them. Wipe the insects off the plant and smash them inside the paper towel. You can also use sticky tape or packing tape to pull the aphids off of the plant. Smash the aphids by folding the tape onto itself.Luckily, pollinator gardens attract other beneficial insects, like parasitic wasps, that can assist in aphid control. Another pest to look out for is the large milkweed bug (Oncopeltus fasciatus). This insect is easy to identify with its dark orange and black coloration. Many gardeners choose to leave this insect alone, as it is part of the ecosystem. Unfortunately, milkweed bugs interrupt seed production by attacking the seed pods. If producing viable seed is important to you, you can remove these insects simply by picking them off the plant and dropping them into a cup of soapy water.It is important to remember that any insecticide that you use will also affect the wonderful pollinators that you work hard to conserve. The monarch migration is coming in a few weeks, so watch for pests, reap the rewards of the hard work of butterfly gardening and enjoy the show.To follow the monarch migration and to report your butterfly sightings, visit Journey North at journeynorth.org/monarchs. For many years, this organization has tabulated the reports of citizen-scientists and is a great resource for school groups. Monarch Watch, accessible at monarchwatch.org, provides online information about these insects and their habitat needs. Contact your local University of Georgia Cooperative Extension office for more information about butterfly gardening and habitat building by visiting extension.uga.edu.last_img read more

Macron set to warn France virus lockdown must go on

first_imgPresident Emmanuel Macron is on Monday expected to warn France its lockdown to combat the coronavirus must go on for several more weeks at least, while also outlining how the country will recover from the crisis.At just after 8:00 pm (1800 GMT), Macron will give his third prime-time televised address to the nation on the epidemic from the Elysee palace. In his last, he announced the nationwide lockdown to slow the spread of the virus from March 17.This speech will come after the first indications of a tentative easing of the crisis in France and that the lockdown is starting to have an effect, with the epidemic starting to plateau, albeit at a high level. France on Sunday reported a lower number of COVID-19 fatalities over the last 24 hours, with 315 deaths in hospital over the last day, compared with 345 the previous day.Its total toll from the coronavirus epidemic, including those who have died in nursing homes, now stands at 14,393, the health ministry said.And for the fourth consecutive day in a row, the number of patients in intensive care fell with 35 fewer patients, making a total of 6,845 people needing such treatment.But officials have warned that the situation remains serious — especially in the Ile-de-France region around Paris — with no rapid return to normal in sight. Topics :center_img May lockdown? Macron will be looking to steer a careful line between warning France that an early relaxation of the lockdown could be disastrous, while reassuring people that the government has a plan to get the country back to normal.The lockdown has confined the French to their homes for almost a month, with only brief trips allowed outside for shopping and other essential errands.Sources said Macron would announce that the lockdown must be extended beyond its current April 15 expiration date until well into May.The Journal du Dimanche newspaper reported that the restrictions could continue until the end of May, with schools only reopening with the new academic year in September. A source close to Macron told AFP that he should speak in terms of a date during May for the end of the lockdown, but after the May 8-10 holiday weekend.The date should be “long enough away so everyone understands the effort that still needs to be made but sufficiently close to sketch out how France will look afterwards”.He is not expected to issue rulings on specific questions, such as whether the wearing of masks in public should become generalized, or on tracing and testing.The source added that so far there had been no decision on keeping schools closed until September.last_img read more

Five key skills all successful fmcg buyers have

first_imgSource: The GrocerGreat buyers have an extensive knowledge of what’s on their competitor’s shelvesMarket awarenessSuccessful buyers have a genuine interest in their category and know exactly what’s going on in the market. They’ll read lots of trade magazines, know what their competitors are doing and have a good grasp on the effect their category decisions have on the wider market.They’re tasked with growing market share, so buyers for big retailers need to be aware of what’s happening within their category at the discounters and in the convenience market, too.There’s also the small matter of understanding what consumers want from a category and trying to anticipate their needs. Outside of market data, buyers also deal with spreadsheets for their promotional calendar, pricing, volume vs profit and forecasting, so strong excel skills are a must.And to top it off, all categories have a regular flow of NPD to be managed. Every new product will come with its own calendar of tasks to be completed.Sharp commercial acumenBuyers need to understand how to plan, manage and implement budgets. Not only should they be aware of their top line sales, but also their bottom line in the short and long term.They’re also joint business planning, considering the commercial outcomes for their retailer and suppliers – so a buyer has to have strong money management skills.Master negotiating skillsBuyers spend a lot of time sitting in front of suppliers. They need to be able to negotiate the best deals that work for both parties: that might mean convincing suppliers to provide marketing support, or asking them to shell out money for certain shelf space. It’s always a case of give and take, and a great buyer can use their influence to get the best outcome. Buyers who work in chilled categories also have to juggle the short shelf lives of productsThe ability to keep calm under pressureBuyers need to be incredibly fast decision makers. If their boss sets a target and there’s limited space on shelf, there’s no time for flapping. If the category is underperforming, buyers need to act quickly and make tough decisions to still make their KPIs.And on top of this, buyers working in chilled have to work even faster because of their products’ short shelf lives. Are you a buyer working in own-label?center_img Enter The Grocer’s Best of Own-Label Awards for free today and get the recognition you deserve. We’ll be crowning Best Own-Label Buyer, Best Own-Label Range and Best Own-Label Team among several other enviable titles. Check out the rest of the categories and enter for free here. They’re at the forefront of food and drink trends, they introduce exciting new flavour combinations that excite the masses and take part in endless tasting sessions. To the outside world it can look like buyers have one of the best jobs in the world. But, the reality is, there’s a lot more to the job than trying out new products.We spoke to Emilie Gregson from specialist fmcg recruitment agency Signature Career Management to find out the most important skills that all of the UK’s best fmcg buyers have in their arsenal.,Strong excel skills are important to keep track of promotional calendars and pricingStrong data and organisational skillsSomeone who can’t read and interpret data isn’t going to cut it as a buyer.Buyers can’t rely on suppliers to give them the market analysis they need to plan their category. Some suppliers might offer up unbiased reports, but others will only provide the figures they want a buyer to see. And buyers could be dealing with up to 50 different suppliers all telling them different things – it’s their job to cut through the noise and find the real story within the data. And startups won’t have any data at all.last_img read more

Dutch pensions regulator lists characteristics of best recovery plans

first_imgHowever, the watchdog also noted that recoveries were limited by falling interest rates and rising life expectancy.According to the DNB, equity markets fell by 80% between June 2007 and the end of 2008, while interest rates fell by 20% over the same period.“Over the last five years, the equity index has returned to the initial level, whereas interest rates have fallen further,” it said, adding that the funding index remained somewhere in between.The regulator explained that, using the typical investment mix and interest hedge in the Netherlands, changes in interest rates would have a roughly 50% impact on coverage ratios, whereas equity market changes would have a 40% impact. The DNB’s evaluation of the recovery plans confirmed that 30 pension funds had to apply rights cuts last April, in order to achieve the required funding of 105%.The most recent round of discounts hit 650,000 active participants, 405,000 pensioners and more than 1.2m deferred members in total, while the weighted average of the cuts was 0.84%, according to the supervisor.It said that one pension fund had used the option to limit last April’s discount to 7%, and that the scheme would apply an additional cut in future. Equity investments and hedges of the interest risk on liabilities have been the main drivers for Dutch pension funds’ recoveries since the onset of the financial crisis, according to pensions regulator De Nederlandsche Bank (DNB). Following an evaluation of more than 140 short-term recovery plans, the regulator concluded that schemes with a relative large equity allocation in addition to an interest hedge showed the strongest recoveries.In 2009, approximately three-quarters of Dutch pension funds had to submit a five-year recovery plan, mapping out how they aimed to achieve funding of at least 105% at the end of 2013.The DNB found that the average coverage ratio improved by 15 percentage points over the last five years and attributed the increase largely to the strength of equity markets.last_img read more

Hillingdon drops SSgA for LGIM on index-tracking mandate

first_imgThe London Borough of Hillingdon Pension Fund has hired Legal & General Investment Management (LGIM) to oversee a £215m (€238m) index-tracking mandate.The local authority fund, which had £810m, hired LGIM to replace State Street Global Advisors, first appointed in late 2008.According to its most recent annual report, from March 2015, SSgA’s mandate for Hillingdon was worth £161m, equivalent to 20% of scheme assets.Philip Corthorne, chair of the fund’s pensions committee, cited a desire to cut management costs when describing the reasons for LGIM’s hire. “We have chosen LGIM because of its expertise in index-tracking fund management and its broad range of cost-effective pooled funds, which will enable us to take a step closer towards the government’s pooling agenda, with management and reporting of the mandate to eventually be carried out by the pool.”LGIM was among the first managers hired by the London CIV, the pooling vehicle for London’s local authority funds, and was set to manage a number of passive equity sub-funds.The manager is the largest single manager of local authority assets, overseeing £44bn, a figure significantly boosted after it won a £6.5bn passive mandate from seven pension funds in late 2015.last_img read more

Car hits center island; 1 killed

first_imgChiron Morales died of head and body injuries, a police report showed. His companion Police Staff Sergeant Elren Ismael survived the crash and was recuperating at the Ibajay District Hospital.    ILOILO City – A man was killed while a police officer was injured when the car they were riding crashed against the road’s center island in Barangay Poblacion, Nabas, Aklan. The victims were both residents of Barangay Laguinbanwa, Ibajay, Aklan.center_img According to the report, it was not immediately established what circumstance led to the accident that happened around 6:45 p.m. on Monday./PNlast_img