View post tag: Navy View post tag: Boxer For a second consecutive year, the amphibious assault ship USS Boxer (LHD 4) was named winner of the Retention Excellence Award for outstanding Sailor retention for 2012.The Retention Excellence Award, also known as “Golden Anchor Award,” is awarded annually to commands that meet or exceed the retention criteria set forth by the Chief of Naval Operations. Commands must also score a minimum of 85 on their annual command career information program review to qualify for the award. “The award is a significant accomplishment for the crew and validates the commitment our leaders have to the Sailors onboard,” said Navy Counselor 1st Class (SW/AW) Derek Reynolds from Boxer’s career counselor office. Chief Navy Counselor (AW/SW) Jayne Epaloose, Boxer’s command career counselor, agreed that the award represents a total shipboard effort to have more Boxer Sailors stay Navy. “This award means Boxer leadership cares about its Sailors,” said Epaloose.As a trophy for winning the award, the command will be allowed to keep the ship’s anchors painted gold for another year. “Our anchors are gold and that tells the fleet what Boxer is all about,” added Epaloose.[mappress]Naval Today Staff, February 11, 2013 View post tag: Second View post tag: Naval View post tag: receives February 11, 2013 View post tag: Excellence Training & Education View post tag: News by topic Back to overview,Home naval-today USS Boxer Receives Retention Excellence Award for Second Time View post tag: award View post tag: Retention View post tag: time Share this article View post tag: USS USS Boxer Receives Retention Excellence Award for Second Time
View post tag: Dynamic Manta NATO’s major Mediterranean Sea anti-submarine warfare exercise Dynamic Manta is getting underway at the Italian port of Catania on Monday, March 5.The two-week drill will take place in the Ionian Sea and will be joined by navies from 10 allied countries.Dynamic Manta is an annual NATO exercise in the Mediterranean Sea aimed at providing complex and challenging scenarios for anti-submarine and anti-surface warfare skills development.Last year’s edition of the exercise saw the participation of nine submarines, 10 surface ships and nine maritime patrol aircraft.Submarines so far confirmed to be taking part in Dynamic Manta 2018 include Royal Canadian Navy submarine HMCS Windsor, Hellenic Navy submarine HS Matrozos, Turkish submarine TCG Preveze and Spanish Navy’s ESPS Mistral.According to a NATO infographic, the exercise will host ten nations, six submarines and nine surface ships for the evolutions. Authorities March 5, 2018 Share this article View post tag: NATO NATO ASW drill Dynamic Manta kicks off in Italy Back to overview,Home naval-today NATO ASW drill Dynamic Manta kicks off in Italy View post tag: ASW
CATE SISCOROCHELLE SERRAPHILLIP DAVISSUNNI ZIMMERTINA PORTELLO OUIGLEYE LON WALTERSRANDALL FORSTERCORY RAYJORDAN BAERJESSE DANIELCHARLES D. EUBANKDONNA ROBINSONKYLE G JOHNSONKATHLEEN KRISTENPHILIPS DAVISE LON WALTERSKELLY CHANDLERKELLY GATESMARCIA BLEVINSED KARGESCHINA PHELPSANDREW BELLEMMA LENTOJOSH TURNERBRADLEY SMITHBROCK LANCETIM DEISHERJOHN FRANKSAMANDA HENNDEBORAH WINTNERCOURTNEY GOUSMANSTAN LEVCOBRECK BITTERED KARGESSALOME LaMARCHEEVAN OTTERCHRIS BORNMELANIE BOZSAGLORIA WEBBORNSHERYL SANDERSKIMBERLY ANN GREERJAMIE FUCHSBRENDA HUGHESMARCIA BIVINSED KARGESC LARRY RHODESCHINA PHELPSJOHN WOODALLEVELYN MaVEETYSCHARIAS K. GRAVESSTEVEN PIRNATNATHAN BAYNECHRIS LANTAFFJIMMY LEFTERDANIEL DiLEGGEJOSH TURNERBILL BETZEDIASRISINTA ARIYASTEVEN PIRNATNATHAN BAYNEMARVIN C HINTONJOHN LUEDKEBRENT FEULNERJOE TEMPLETONBOB DEGRAFFENREIDJAMES BILLMONICA SCHREIBERKAREN DOERNER HILLKEEITH KERNEYJOSH TURNERBILL BETZTIFFANY NUNN STEPTOJAMES BRINKMEYERCHRIS BROWNMICHAEL PRUITTROBERT MONEYRICKIE DUPONT SRWAYNE HARTSTACEY LYNN MAYESFacebookTwitterCopy LinkEmail
WASHINGTON – Federal transportation officials have assigned the Gateway rail tunnel and other components of the massive infrastructure project a new rating that further jeopardizes the chances of winning grant money from Washington.A story on Politico.com says the Federal Transit Administration sent an annual funding report to Congress on Monday for its Capital Investment Grants Program that assigned a “Medium-Low” rating to the proposed $13 billion Hudson River tunnel, the second-lowest on a five-point scale. It was the first time the grant application had received a formal rating. The FTA also reduced the rating of the Portal Bridge North project from “Medium-High” to “Medium-Low.” That bridge replacement that would fix one of the single-greatest bottlenecks on Amtrak’s Northeast Corridor line.Those involved in the Gateway Program said the change was likely to put chances of receiving federal funding under the New Starts program in serious jeopardy.The Trump administration rejected an Obama-era agreement to cover half the cost of the broader $30 billion Gateway Program, which calls for constructing two new tubes connecting New Jersey to midtown Manhattan and repairing the existing tunnel that is now falling apart. The White House has also proposed ending the New Starts program, but Congress has so far protected the funding source.“In case it wasn’t clear before, President Trump today tried to land another death blow to Gateway by having his Federal Transit Administration (FTA) vindictively and inexplicably downgrade the project in order to cut off critical federal funding,” Sen. Bob Menendez (D-N.J.) said in a statement on Monday.In the case of the Portal Bridge project, which previously received a rating in February 2017 and was estimated to cost $1.6 billion, the FTA is taking the position that the amount of committed or budgeted funding from other sources had fallen from 57 percent to 21 percent of the total cost. The FTA said that is a primary reason the rating was reduced. The new ratings were issued in November and, according to a person familiar with the Gateway application, did not factor in any information received in October, when new details had become available.John D. Porcari, the interim executive director of Gateway Program Development Corp., said the ratings fail to take into account the commitments from New York and New Jersey. The states have agreed to split half the cost of the tunnel project, putting up $5.5 billion, though they’ll need federal loans in order to do so. The grant application asks the federal government to cover the remaining costs.Porcari said the Portal Bridge application, in which local agencies would also cover about half the total cost, “has only been improved with each updated submittal” since the first rating was issued. He noted early construction work has been underway for several months.“We are surprised and disappointed by the sudden downgrade based on what appears to be changing evaluation criteria,” Porcari said. “We continue to work closely with USDOT to strengthen our funding applications and remain confident that the merits of the projects warrant significant federal investment.”
We are all saddened by the tragic death this morning before the Harvard-Yale football game. Our thoughts are with the victim and her family and friends.We also express our sympathy and concern for the two other people who were injured, one of whom is a staff member at Harvard’s Division of Continuing Education (DCE). Our DCE colleague was treated at and released from a hospital in New Haven earlier this afternoon. To protect her privacy, we are not releasing her name at this time.
With the discovery of a compound that can slow the degradation of insulin in animals, scientists at Harvard have opened the door to a potential new treatment for diabetes.The new approach, described by David Liu, professor of chemistry and chemical biology, and Alan Saghatelian, associate professor of chemistry and chemical biology, uses the compound to inhibit insulin-degrading enzyme (IDE). Inhibiting IDE in mice, they have shown, elevates insulin levels and promotes insulin signaling in vivo. Eventually, using this compound in patients may help maintain higher insulin levels to improve glucose tolerance and thereby treat diabetes. The discovery of the compound, and tests demonstrating its efficacy in mice, are outlined in a May 21 paper in the journal Nature.“This work validates a new potential target for the treatment of diabetes,” Liu said. “What we show is that inhibiting IDE in an animal can improve glucose tolerance under conditions that mimic the intake of a meal if you administer this compound beforehand.”For decades, insulin-based diabetes treatments consisted of three main strategies — inject insulin into diabetics, provide drugs that stimulate insulin secretion, or administer drugs that make the body more sensitive to insulin.“What’s been missing has been the ability to regulate the degradation of insulin,” Saghatelian said. “The technological leap we’ve made was in identifying a molecule that allows that to happen. This opens up a new avenue to control insulin signaling in vivo.”To identify the new molecule, Liu, Saghatelian, and their co-workers turned to DNA-templated synthesis, a method of creating molecules that self-assemble according to an attached DNA sequence. The system works by combining DNA “templates,” or short segments of DNA, with the chemical building blocks of molecules, each of which is linked to a complementary piece of DNA. As the DNA segments bind, the building blocks are brought together and react with one another, forming molecules of greater complexity. The composition of the resulting molecules can be identified by sequencing their associated DNA strands.“We took a library of about 14,000 DNA templates and combined it with several sets of DNA-linked reagents,” Liu said. “The resulting synthesis of about 14,000 small molecules was largely driven by, and programmed by, DNA base pairing. At the end of that process, we had 14,000 strands of DNA, each with a unique compound at its end.”Researchers then took that library of DNA-linked compounds and incubated it with IDE in the hope that some might bind to the enzyme.“Our hypothesis was that the molecules that were retained by IDE might modulate IDE’s activity,” Liu said. “In this case, right out of the library, we found quite a potent and selective inhibitor. Perhaps most important, this molecule had a good half-life in animals, so it could be used to answer the 60-year-old question of what happens when you slow down the natural degradation of insulin in the body.”Identifying a molecule that could inhibit IDE, however, was only the first step.Researchers were also able to show that the compound remained active in the body, and experiments with mice showed that it was able to help regulate blood-sugar levels.“To validate that this strategy of slowing the degradation of insulin is actually therapeutically useful, we have to show that this compound can transiently inhibit the target, and show that it has a benefit in animals,” Liu said. “That is what we demonstrate in this study.”In addition to pointing the way toward a new way to treat diabetes, researchers uncovered information about how IDE works in the body.“In the process of resolving some seemingly paradoxical results, we discovered that IDE is actually somewhat misnamed,” he said. “It doesn’t just degrade insulin, it degrades at least two other important glucose-regulating peptide hormones, glucagon and amylin.”While the discovery of the molecule is exciting, Liu emphasized that it may still be some time before the compound finds its way onto pharmacy shelves.“To develop a drug requires a number of additional tests and developments,” he said. “But this work validates IDE as a new target for the treatment of diabetes, and it provides experimental tools that can be used to develop this compound further into potential therapeutic leads.”“What this paper has done is given a proof of concept that targeting this protein is the way to go,” Saghatelian said. “To make the leap from this molecule to a drug, there are other factors that need to be optimized. But we’ve hung the carrot out there for the pharmaceutical industry and other labs to start looking at IDE as a potential target for treating diabetes, and to push through the remaining obstacles that are there. We’ve shown it’s worth the effort to look into this more deeply, and hopefully what we’ve done is opened people’s eyes to IDE as a valid therapeutic target.”Researchers from Stony Brook University, the Albert Einstein College of Medicine, the University of California, Irvine, and the University of Chicago contributed to the research.
View Comments Ben Platt It’s Friday, which means it’s time to head home, jump into bed, marathon some Netflix and dreamcast Aaron Tveit’s hair in Grease Live! But before you begin those super-fun weekend activities, we’re recapping the wildest, wackiest things that happened on the Great White Way this week. From Alex Sharp’s sexy and regal hip-hop musical to your new favorite Midtown brunch destination, here are the lessons of the week!Groffsauce Is Into Old People (Like Himself)If you want to give Jonathan Groff a gift at the Hamilton stage door, maybe go for large-print books or a some orthopedic footwear. The 30-year-old King George told us that Spring Awakening coming back makes him feel old. “I’m into it. I’m happy to be old,” he said. That’s so nice to hear, Jonathan. I SAID THAT’S SO NICE TO HEAR. Just kidding. Groff fits right in with the young, hip group at Hamilton. But we also have another show in mind for him.Shakespeare Is a Rotten LibrarianChristian Borle may have a Tony for Something Rotten!, but he’s urging you to be just the opposite. In Heidi Blickenstaff’s latest vlog, Borle announced the launch of @RottenActs: Tweet them your random acts of kindness, and you might just win won of his books from the nook! Suggestions include befriending a cartoon character, buying the next round or throwing a surprise party for someone in a public bathroom.Benedict Cumberbatch Is a West End PattiSpeaking of people who aren’t on social media but want others to be, Benedict Cumberbatch has a message for you to “hashtag the shit out of.” Apparently, the proclamation of Patti LuPone hasn’t yet reached its way to London, since people are recording his performance in Hamlet ,and he can definitely see the little red lights. Don’t you remember what the Bard wrote? “This above all: to thine own self be true and STOP TAKING PICTURES RIGHT NOW.”Alex Sharp Wants More Broadway QueensIf Lin-Manuel Miranda needs any help working through ideas for his next musical, he needn’t look further than a block up at the Barrymore Theatre. At the Hamilton opening night, Curious Incident Tony winner Alex Sharp revealed that he thinks a hip-hop musical about Queen Victoria would be “sexy.” That’s not the first word that comes to mind for us, but Sharp is British, so we trust him on these things.New York’s Hottest Brunch Spot Is…We’re all about Friday bagels and booze at Broadway.com HQ, but for the cast of A Gentleman’s Guide to Love & Murder, Sunday is Funday. As Bryce Pinkham showed us in the inaugural episode of his vlog, the cast kicks the day off with brunch before the matinee. Then, after the show, they all gather in his dressing room for a drink! Carbs, show tunes and whiskey? You’re speaking our language!Save Room for Broadway PieSara Bareilles’ Waitress musical is still in the oven over at the American Repertory Theater, and we can’t wait for her to serve us a slice at the Brooks Atkinson this spring. We’re still waiting on exact dates, but the tuner is set to begin performances sometime in March. We’re holding out for March 14, which, as math nerds and dessert enthusiasts know, is Pi Day. We’ll be at that first preview. With pie.The Music Box Needs More Shelf SpaceYou know what show is starting on Pi Day? [Takes deep breath] Shuffle Along, Or, The Making of the Musical Sensation of 1921 and All That Followed. Hopefully, the Music Box Theatre will be able to build some more storage space. Between Audra McDonald, Billy Porter and Brian Stokes Mitchell, the still incomplete cast has eight Tonys. With those three hot stars, plus Joshua Henry and Brandon Victor Dixon, we suspect there’ll be more to come in June.The Sex Is in Wayne Brady’s HeelAfter winning an Emmy for Whose Line Is It Anyway?, Wayne Brady is quick on his feet, so to speak. That’ll soon come in handy, because those big, red kinky boots are no joke. The TV favorite will assume the role of Lola from Billy Porter, who, as you’d know if you were paying attention four sentences ago, is going on to star in Shuffe Along and the Title We Haven’t Memorized Yet. We can’t wait to see what Brady will look like all dolled up.Heights Is Going Scrappy, Not Snappy¡No me diga! The In the Heights movie has a new screenplay! But…it’s still a ways off. Lin-Manuel Miranda recently explained the setbacks the project has faced since 2008, and that a “scrappy $15 million movie” is in the works. Hey, plenty of movies have had lower budgets than expected. Just look at Paranormal Activity. Maybe you can have a poltergeist or something cause the barrio blackout? We hear Kristin Chenoweth likes to play evil now. Just a suggestion.We Punched Ben Platt’s K-CardWhile side by side with Susan Blackwell, the Pitch Perfect fave and Dear Evan Hansen star revealed that he had never done anything “remotely related” to flying a kite. Which makes total sense no sense at all. You’re from L.A. and you’ve never flown a kite? Fortunately, Blackwell was on hand to pop his kite-flying cherry, and he quickly got the hang of it. He was even able to do it one-handed! (Still talking about kite flying, children.) Star Files Jonathan Groff
It’s the last month of summer folks. While we may be sad that our sunbathing and swimming days are almost over for the year, we couldn’t be more excited about our September issue! In this issue, we head down the singletrack of the region’s best Ride Centers, see how fast we can hike the Appalachian Trail, and we swing by the Jungles of Middle Tennessee to visit the elephants who call them home. That’s right, we said elephants in Middle Tennesse.
By DVIDS November 17, 2020 Personnel from U.S. Army South, Brooke Army Medical Center, and the Central Military Medical Hospital of Buenos Aires, Argentina, participated in a virtual COVID-19 lessons learned exchange October 21 to share best practices in response to the pandemic and other health-related topics.The idea for the exchange was developed in July during a routine engagement between Major General Daniel R. Walrath, U.S. Army South commanding general, and Argentine Army Major General Agustín Humberto Cejas, chief of the Army General Staff, as both agreed the exchange of timely and life-saving information was paramount to the protection of our forces.“The U.S. and its allies and partners are responding to shared common COVID-19 themes such as rapid and aggressive action against the virus and its transmission; command, control, and coordination of COVID-19 response measures; and the protection of our Force and families,” said Major Christopher Smith, Argentine desk officer, U.S. Army South Security Cooperation Directorate.During the exchange, a panel of medical professionals from Brooke Army Medical Center discussed lessons learned with a panel of Argentine Army doctors in response to the COVID-19 pandemic. Information shared included best practices relating to how to prepare for the pandemic, patient care management, testing methods, and protocols to protect medical personnel.“Events like this increase the readiness of our forces and improve force protection capacities between the U.S., our allies, and partners,” said Maj. Smith.Using these practices will allow the U.S. Army and Argentine Army to successfully mitigate some of the impact that COVID-19 has had on the units, civilian personnel, family members, as well as the military bases.“The U.S. and Argentine armies work closely through the [U.S.] Department of State and U.S. Southern Command to promote mutual multilateral interoperability and counter common threats through bilateral and multilateral engagements, joint training exercises, and participate in reciprocal personnel and student exchanges,” said Maj. Smith.These defense partnerships are vital to security and prosperity in the hemisphere and to our collective ability to meet complex global challenges.
by: Cyndy StewartFinancial institutions are not immune from having to invest in technology. At some point, in order to remain efficient and serve your customers, you will be forced to adapt to and implement new technology.Effectively using technology allows you to save time, maximize employee resources, remain competitive, reduce your regulatory burden, and become more efficient and productive. Of course, shopping for and deploying new technology can be an arduous process. There are often multiple vendors that can offer similar capabilities, pricing models, and benefits, and making the right choice for your financial institution, with your unique needs, can take time and a pretty intense due diligence process.As you’re evaluating your technology needs and trying to find software and services to meet your needs and goals, consider the benefits of purchasing software as a package from one vendor, rather than going the “a-la-carte” route.Many software solutions providers package multiple services together to give users a more robust experience. For example, Microsoft® Office is sold as a suite of products including Word, Excel, PowerPoint, and Outlook, all of the tools that an individual or student needs to get the most out of their home office experience. Sure, you could purchase Word by itself, but the real value comes from the integration of the other products working together. More and more, it’s becoming an industry norm for providers to offer software and services in packages or levels so that users have a comprehensive solution, while still meeting their budget. continue reading » ShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr