We are all saddened by the tragic death this morning before the Harvard-Yale football game. Our thoughts are with the victim and her family and friends.We also express our sympathy and concern for the two other people who were injured, one of whom is a staff member at Harvard’s Division of Continuing Education (DCE). Our DCE colleague was treated at and released from a hospital in New Haven earlier this afternoon. To protect her privacy, we are not releasing her name at this time.
With the discovery of a compound that can slow the degradation of insulin in animals, scientists at Harvard have opened the door to a potential new treatment for diabetes.The new approach, described by David Liu, professor of chemistry and chemical biology, and Alan Saghatelian, associate professor of chemistry and chemical biology, uses the compound to inhibit insulin-degrading enzyme (IDE). Inhibiting IDE in mice, they have shown, elevates insulin levels and promotes insulin signaling in vivo. Eventually, using this compound in patients may help maintain higher insulin levels to improve glucose tolerance and thereby treat diabetes. The discovery of the compound, and tests demonstrating its efficacy in mice, are outlined in a May 21 paper in the journal Nature.“This work validates a new potential target for the treatment of diabetes,” Liu said. “What we show is that inhibiting IDE in an animal can improve glucose tolerance under conditions that mimic the intake of a meal if you administer this compound beforehand.”For decades, insulin-based diabetes treatments consisted of three main strategies — inject insulin into diabetics, provide drugs that stimulate insulin secretion, or administer drugs that make the body more sensitive to insulin.“What’s been missing has been the ability to regulate the degradation of insulin,” Saghatelian said. “The technological leap we’ve made was in identifying a molecule that allows that to happen. This opens up a new avenue to control insulin signaling in vivo.”To identify the new molecule, Liu, Saghatelian, and their co-workers turned to DNA-templated synthesis, a method of creating molecules that self-assemble according to an attached DNA sequence. The system works by combining DNA “templates,” or short segments of DNA, with the chemical building blocks of molecules, each of which is linked to a complementary piece of DNA. As the DNA segments bind, the building blocks are brought together and react with one another, forming molecules of greater complexity. The composition of the resulting molecules can be identified by sequencing their associated DNA strands.“We took a library of about 14,000 DNA templates and combined it with several sets of DNA-linked reagents,” Liu said. “The resulting synthesis of about 14,000 small molecules was largely driven by, and programmed by, DNA base pairing. At the end of that process, we had 14,000 strands of DNA, each with a unique compound at its end.”Researchers then took that library of DNA-linked compounds and incubated it with IDE in the hope that some might bind to the enzyme.“Our hypothesis was that the molecules that were retained by IDE might modulate IDE’s activity,” Liu said. “In this case, right out of the library, we found quite a potent and selective inhibitor. Perhaps most important, this molecule had a good half-life in animals, so it could be used to answer the 60-year-old question of what happens when you slow down the natural degradation of insulin in the body.”Identifying a molecule that could inhibit IDE, however, was only the first step.Researchers were also able to show that the compound remained active in the body, and experiments with mice showed that it was able to help regulate blood-sugar levels.“To validate that this strategy of slowing the degradation of insulin is actually therapeutically useful, we have to show that this compound can transiently inhibit the target, and show that it has a benefit in animals,” Liu said. “That is what we demonstrate in this study.”In addition to pointing the way toward a new way to treat diabetes, researchers uncovered information about how IDE works in the body.“In the process of resolving some seemingly paradoxical results, we discovered that IDE is actually somewhat misnamed,” he said. “It doesn’t just degrade insulin, it degrades at least two other important glucose-regulating peptide hormones, glucagon and amylin.”While the discovery of the molecule is exciting, Liu emphasized that it may still be some time before the compound finds its way onto pharmacy shelves.“To develop a drug requires a number of additional tests and developments,” he said. “But this work validates IDE as a new target for the treatment of diabetes, and it provides experimental tools that can be used to develop this compound further into potential therapeutic leads.”“What this paper has done is given a proof of concept that targeting this protein is the way to go,” Saghatelian said. “To make the leap from this molecule to a drug, there are other factors that need to be optimized. But we’ve hung the carrot out there for the pharmaceutical industry and other labs to start looking at IDE as a potential target for treating diabetes, and to push through the remaining obstacles that are there. We’ve shown it’s worth the effort to look into this more deeply, and hopefully what we’ve done is opened people’s eyes to IDE as a valid therapeutic target.”Researchers from Stony Brook University, the Albert Einstein College of Medicine, the University of California, Irvine, and the University of Chicago contributed to the research.
View Comments Ben Platt It’s Friday, which means it’s time to head home, jump into bed, marathon some Netflix and dreamcast Aaron Tveit’s hair in Grease Live! But before you begin those super-fun weekend activities, we’re recapping the wildest, wackiest things that happened on the Great White Way this week. From Alex Sharp’s sexy and regal hip-hop musical to your new favorite Midtown brunch destination, here are the lessons of the week!Groffsauce Is Into Old People (Like Himself)If you want to give Jonathan Groff a gift at the Hamilton stage door, maybe go for large-print books or a some orthopedic footwear. The 30-year-old King George told us that Spring Awakening coming back makes him feel old. “I’m into it. I’m happy to be old,” he said. That’s so nice to hear, Jonathan. I SAID THAT’S SO NICE TO HEAR. Just kidding. Groff fits right in with the young, hip group at Hamilton. But we also have another show in mind for him.Shakespeare Is a Rotten LibrarianChristian Borle may have a Tony for Something Rotten!, but he’s urging you to be just the opposite. In Heidi Blickenstaff’s latest vlog, Borle announced the launch of @RottenActs: Tweet them your random acts of kindness, and you might just win won of his books from the nook! Suggestions include befriending a cartoon character, buying the next round or throwing a surprise party for someone in a public bathroom.Benedict Cumberbatch Is a West End PattiSpeaking of people who aren’t on social media but want others to be, Benedict Cumberbatch has a message for you to “hashtag the shit out of.” Apparently, the proclamation of Patti LuPone hasn’t yet reached its way to London, since people are recording his performance in Hamlet ,and he can definitely see the little red lights. Don’t you remember what the Bard wrote? “This above all: to thine own self be true and STOP TAKING PICTURES RIGHT NOW.”Alex Sharp Wants More Broadway QueensIf Lin-Manuel Miranda needs any help working through ideas for his next musical, he needn’t look further than a block up at the Barrymore Theatre. At the Hamilton opening night, Curious Incident Tony winner Alex Sharp revealed that he thinks a hip-hop musical about Queen Victoria would be “sexy.” That’s not the first word that comes to mind for us, but Sharp is British, so we trust him on these things.New York’s Hottest Brunch Spot Is…We’re all about Friday bagels and booze at Broadway.com HQ, but for the cast of A Gentleman’s Guide to Love & Murder, Sunday is Funday. As Bryce Pinkham showed us in the inaugural episode of his vlog, the cast kicks the day off with brunch before the matinee. Then, after the show, they all gather in his dressing room for a drink! Carbs, show tunes and whiskey? You’re speaking our language!Save Room for Broadway PieSara Bareilles’ Waitress musical is still in the oven over at the American Repertory Theater, and we can’t wait for her to serve us a slice at the Brooks Atkinson this spring. We’re still waiting on exact dates, but the tuner is set to begin performances sometime in March. We’re holding out for March 14, which, as math nerds and dessert enthusiasts know, is Pi Day. We’ll be at that first preview. With pie.The Music Box Needs More Shelf SpaceYou know what show is starting on Pi Day? [Takes deep breath] Shuffle Along, Or, The Making of the Musical Sensation of 1921 and All That Followed. Hopefully, the Music Box Theatre will be able to build some more storage space. Between Audra McDonald, Billy Porter and Brian Stokes Mitchell, the still incomplete cast has eight Tonys. With those three hot stars, plus Joshua Henry and Brandon Victor Dixon, we suspect there’ll be more to come in June.The Sex Is in Wayne Brady’s HeelAfter winning an Emmy for Whose Line Is It Anyway?, Wayne Brady is quick on his feet, so to speak. That’ll soon come in handy, because those big, red kinky boots are no joke. The TV favorite will assume the role of Lola from Billy Porter, who, as you’d know if you were paying attention four sentences ago, is going on to star in Shuffe Along and the Title We Haven’t Memorized Yet. We can’t wait to see what Brady will look like all dolled up.Heights Is Going Scrappy, Not Snappy¡No me diga! The In the Heights movie has a new screenplay! But…it’s still a ways off. Lin-Manuel Miranda recently explained the setbacks the project has faced since 2008, and that a “scrappy $15 million movie” is in the works. Hey, plenty of movies have had lower budgets than expected. Just look at Paranormal Activity. Maybe you can have a poltergeist or something cause the barrio blackout? We hear Kristin Chenoweth likes to play evil now. Just a suggestion.We Punched Ben Platt’s K-CardWhile side by side with Susan Blackwell, the Pitch Perfect fave and Dear Evan Hansen star revealed that he had never done anything “remotely related” to flying a kite. Which makes total sense no sense at all. You’re from L.A. and you’ve never flown a kite? Fortunately, Blackwell was on hand to pop his kite-flying cherry, and he quickly got the hang of it. He was even able to do it one-handed! (Still talking about kite flying, children.) Star Files Jonathan Groff
It’s the last month of summer folks. While we may be sad that our sunbathing and swimming days are almost over for the year, we couldn’t be more excited about our September issue! In this issue, we head down the singletrack of the region’s best Ride Centers, see how fast we can hike the Appalachian Trail, and we swing by the Jungles of Middle Tennessee to visit the elephants who call them home. That’s right, we said elephants in Middle Tennesse.
By DVIDS November 17, 2020 Personnel from U.S. Army South, Brooke Army Medical Center, and the Central Military Medical Hospital of Buenos Aires, Argentina, participated in a virtual COVID-19 lessons learned exchange October 21 to share best practices in response to the pandemic and other health-related topics.The idea for the exchange was developed in July during a routine engagement between Major General Daniel R. Walrath, U.S. Army South commanding general, and Argentine Army Major General Agustín Humberto Cejas, chief of the Army General Staff, as both agreed the exchange of timely and life-saving information was paramount to the protection of our forces.“The U.S. and its allies and partners are responding to shared common COVID-19 themes such as rapid and aggressive action against the virus and its transmission; command, control, and coordination of COVID-19 response measures; and the protection of our Force and families,” said Major Christopher Smith, Argentine desk officer, U.S. Army South Security Cooperation Directorate.During the exchange, a panel of medical professionals from Brooke Army Medical Center discussed lessons learned with a panel of Argentine Army doctors in response to the COVID-19 pandemic. Information shared included best practices relating to how to prepare for the pandemic, patient care management, testing methods, and protocols to protect medical personnel.“Events like this increase the readiness of our forces and improve force protection capacities between the U.S., our allies, and partners,” said Maj. Smith.Using these practices will allow the U.S. Army and Argentine Army to successfully mitigate some of the impact that COVID-19 has had on the units, civilian personnel, family members, as well as the military bases.“The U.S. and Argentine armies work closely through the [U.S.] Department of State and U.S. Southern Command to promote mutual multilateral interoperability and counter common threats through bilateral and multilateral engagements, joint training exercises, and participate in reciprocal personnel and student exchanges,” said Maj. Smith.These defense partnerships are vital to security and prosperity in the hemisphere and to our collective ability to meet complex global challenges.
by: Cyndy StewartFinancial institutions are not immune from having to invest in technology. At some point, in order to remain efficient and serve your customers, you will be forced to adapt to and implement new technology.Effectively using technology allows you to save time, maximize employee resources, remain competitive, reduce your regulatory burden, and become more efficient and productive. Of course, shopping for and deploying new technology can be an arduous process. There are often multiple vendors that can offer similar capabilities, pricing models, and benefits, and making the right choice for your financial institution, with your unique needs, can take time and a pretty intense due diligence process.As you’re evaluating your technology needs and trying to find software and services to meet your needs and goals, consider the benefits of purchasing software as a package from one vendor, rather than going the “a-la-carte” route.Many software solutions providers package multiple services together to give users a more robust experience. For example, Microsoft® Office is sold as a suite of products including Word, Excel, PowerPoint, and Outlook, all of the tools that an individual or student needs to get the most out of their home office experience. Sure, you could purchase Word by itself, but the real value comes from the integration of the other products working together. More and more, it’s becoming an industry norm for providers to offer software and services in packages or levels so that users have a comprehensive solution, while still meeting their budget. continue reading » ShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr
Forgot Password ? Google LOG INDon’t have an account? Register here Linkedin Log in with your social account Over the past decade, prominent long-running family businesses in the country have found themselves grappling with the chilling existential question of whether they would be able to survive the changing business landscape and maintain their relevance for another 10 years.The fear proved potent enough for several major family ventures as they pulled out all the stops to diversify their businesses, with a number of legacy conglomerates investing heavily in today’s single most disruptive force: technology.Behind these companies’ scramble for survival are a new generation of movers and shakers – the heirs to several of the country’s most notable tycoons who have made a name for themselves through headline-grabbing ventures and accomplishments.According to the PwC 2019 Global NextGen Survey, which was conducted in 69 territories across five continents and i… Topics : Facebook tycoon business wealth wealthy-family Indonesia Putri-Indah-Tanjung Axton-Salim John-Riady Christina-Suriadjaja Victor-Hartono
The event offers not only a culinary dinner and live entertainment, but also celebrates the successes within the industry by presenting three awards. The nominees were recently announced. These are the nominees for the Young Engineer Award.Jesper Elzinga, Van OordElzinga actively strives to introduce environmental and sustainability initiatives within the offshore energy sector. Elzinga was a core member in the development of ideas for oyster rehabilitation in the North Sea which was executed at Luchterduinen and currently being developed for Borssele 5.To protect marine fauna from the potential impacts of windfarm installation Elzinga also spends a significant amount his resources in assessing and mitigating the underwater sound produced constructing upcoming offshore wind projects. In doing so, Elzinga aims to make use of the cutting-edge models and innovate noise mitigations strategies which are developed within Van Oord/ with partners.He was actively involved in the Luchterduinen pilot through which native flat oysters were re-introduced to the North Sea. Now involved in the upscaling of these processes for Borssele 5 in a quest to make further use of offshore wind parks as ecological rehabilitation hubs.Elzinga was also stationed offshore to execute the first full-scale field testing of an underwater noise mitigation system which aims to better protect marine fauna. He was involved in all the different stages of the project (design, testing, implementation and up to end of execution). Elzinga now actively shares the knowledge gained throughout the offshore energy industry.Tom Ashley, Royal IHCAshley was involved in the design of the first Loading Arm system, which was a complex multi-disciplinary technical challenge. He had to develop innovative engineering solutions while leading a team of varying skills and experience.He has filled many functions at Royal IHC, from Lead Design Engineer to the primary on-site Mechanical Engineering support and the Royal IHC engineering lead.During the J-Lay system installation and commissioning Ashley took pride in the support provided to the construction team. The time pressure had to be balanced with maintaining safety and design integrity. Ashley aims to complete any job to specification, on budget and in time and on developing his team to deliver results and grow as engineers.Travis Anthony, ShellAnthony played a crucial role in the development of the water intake riser (WIR) for Prelude FLNG. The WIR is a large, novel and highly complex bundle of steel pipes providing 50,000 m3/hr of cooling water to the FLNG from 150m water depth.He developed the flexible connection between the WIR and FLNG together with Technip and Trelleborg. He pushed the engineering capacities of both contractors to the limit, and sometimes beyond.A key achievement is when analyses became too complex, Anthony proposed to perform tests. He led these tests performed by Trelleborg and demonstrated that the connection works for Prelude. Anthony was rewarded for his excellent engineering work on the WIR and became Shell’s only representative at the construction yard in France.His main tasks were to ensure safety and quality on site, which he performed outstanding. He raised quality issues early, intervened on safety aspects and improved the safety culture on site. A key intervention by Anthony was the observation of a weld at the wrong location having detrimental effect on the fatigue life of the structure. The mistake was corrected and the WIR was successfully delivered to Prelude FLNG, where it was safely installed ahead of schedule. On October 7, the Offshore Energy Opening Gala Dinner and Awards show will be taking place at the Amsterdome in Amsterdam. Let’s take a closer look at the nominees for the Young Engineer Award.
Washington D.C. — New Sparkling Holidays Commemorative Forever stamps featuring classic images of Santa are available for mailing holiday cards and letters this year— a time-honored tradition embraced by millions annually.The Postal Service dedicated the stamps at a special ceremony today at The Inn at Christmas Place in Pigeon Forge, TN.“I have no doubt that the Sparkling Holidays stamps will quickly become favorites,” said Chief Financial Officer and Executive Vice President Joseph Corbett. “These four stamps feature classic images of Santa Claus, painted by Haddon Sundblom for The Coca-Cola Company. The paintings of the rosy-cheeked, smiling, grandfatherly man in his red suit embody the very essence of Santa.”In addition to Corbett, the ceremony included remarks by Justine Fletcher, director of Heritage Communications for The Coca-Cola Company.News of the stamps is being shared using the hashtag #SparklingHolidaysStamps and a video of the ceremony will be available on the Postal Service’s Facebook page.The Sparkling Holidays stamps, sold in booklets of 20, feature four classic portraits of Santa Claus. Taken from larger paintings created by Sundblom, these vintage images were originally published in ads for The Coca-Cola Company from the 1940s through the early 1960s. Sundblom is credited as the individual who most refined the modern image of Santa.In addition to the stamp booklet, a souvenir sheet is available which includes a stamp and depicts a wider scene of one of Sundblom’s paintings chosen for the Sparkling Holidays stamp booklet. In it, Santa is depicted standing by a fireplace holding a book that lists good boys and girls. Three Christmas stockings hang along a mantel decorated with greens and ornaments. Peering over his glasses, Santa reads a note. The use of gold metallic ink, the flow of the type, and the organic shape of the border harken back to graphic styles of the first half of the 20th century.Art director Greg Breeding designed the stamps and the souvenir sheet with existing art by Sundblom.BackgroundSeveral 19th century European works were instrumental in creating character traits that inspired Sundblom’s paintings, including an 1809 portrayal by author Washington Irving of the gift-bearing St. Nicholas as a sage Dutchman rather than the more common previous image of a somber bishop.Santa Claus, as we know him today, originated from the 1821 poem “The Children’s Friend,” which claimed “Santaclaus” delivered toys to good children while riding a sleigh drawn by a flying reindeer. Several years later in the poem “A Visit From St. Nicholas,” the number of reindeer increased to eight and Santa was depicted as a jolly, plump elf who delivered presents Christmas Eve. Beginning in 1863, Cartoonist Thomas Nast embellished Santa’s look in drawings for Harper’s Weekly magazine. He depicted Santa in all manner of guises, from a portly elfin figure to a big-bellied, white-bearded man. In 1931, Sundblom created the first of more than 40 paintings of Santa Claus for The Coca-Cola Company’s holiday advertising campaign.The Sparkling Holidays stamps, sold as Forever stamps, are always equal in value to the current First-Class Mail 1-ounce price. Customers may purchase the stamps and other philatelic products online through the Postal Store at usps.com/shop,by calling 800-STAMP24 (800-782-6724), by mail through USA Philatelic catalog, or at Post Office locations nationwide. The souvenir sheet will only be sold through usps.com or by calling 1-800-STAMP24.The Postal Service receives no tax dollars for operating expenses and relies on the sale of postage, products and services to fund its operations.
The 21-year-old striker snatched a point with his seventh goal of the season to secure a 1-1 draw with West Brom at St James’ Park on Saturday, their first point since February 28. Perez’s strike could not prevent the club from slipping to 17th place in the table, just two points above the drop zone as a result of victories for Sunderland and Leicester. But their fate remains in their own hands with Hull having slipped into the bottom three and facing testing final fixtures against Tottenham and Manchester United. However, a win at Loftus Road could prove decisive, and that will be the only focus for the former Tenerife frontman and his team-mates. Perez told nufcTV: “It has given us a lot of confidence, but we need to focus on the next game, QPR, and just go after those three important points. “It’s a crucial game, a very important game. We need to go there and get the three points. It’s very important.” Summer signing Perez has been something of a revelation for Newcastle having been thrown in at the deep end because of a combination of Papiss Cisse’s protracted absences through injury, the African Nations Cup and suspension, and Emmanuel Riviere’s difficulties settling into English football. His side was trailing to Victor Anichebe’s 32nd-minute header when Ryan Taylor’s free-kick was half-cleared and he drilled a left-foot snapshot past Boaz Myhill and into the bottom corner. Asked if it was his most important goal to date for the club, he said: “Yes, undoubtedly. “We had a really bad start to the game and therefore the goal made up for it. It’s one more goal under my belt, so it was very important.” Press Association Both sides had chances to win the game during a tense second half, with Baggies substitute Saido Berahino being denied by both keeper Tim Krul and the woodwork and Magpies counterpart Sammy Ameobi sending an acrobatic overhead kick just too high at the death. However, they had to make do with a point apiece, a satisfactory reward for the home side in the circumstances, although two fewer than they had hoped for. Nevertheless, under-fire head coach John Carver breathed a sigh of relief after fearing the worst as the players lined up in the tunnel before kick-off following his team’s capitulation at Leicester seven days earlier. He said: “It was probably the worst game we could have had following last week because I looked at the two sides in the tunnel and it was like Land of the Giants. “They were all 6’4″ centre-halves at the back, we had 5’7″ jockeys, and that’s something we have got to look at because set-plays are important.” The draw handed West Brom the point they needed to mathematically seal their presence in next season’s Barclays Premier League and leave manager Tony Pulis delighted with his players, who have taken 24 points from the 17 league games they have played since his appointment. Pulis said: “Yes – and only just got safe now, which shows how well the players have done. “It’s been absolutely fantastic. If you spin it round, we could have been on 48, 50 points if we had done the same in the first half of the season. “They have done fantastically, they have done really, really well and I’m really pleased for them.” Ayoze Perez is targeting victory at QPR to further ease Newcastle’s relegation fears after bringing an end to their eight-game losing streak.